Few gallerists set out with a blue-chip résumé like Hannah Hoffman’s: The daughter of the renowned arts patron (and National Lampoon founder) Robert K. Hoffman, she studied art history at Boston University, interned with art adviser Allan Schwartzman, and took family trips to Rome, where her father once “rented” the Sistine Chapel for a private viewing with the artist Cy Twombly, who served as a guide. Having further honed her eye during stints in the New York galleries Luxembourg & Dayan and, recently, Gavin Brown’s Enterprise, Hoffman, 27, is going it alone, opening a 3,500-square-foot shop in Hollywood in mid-May. “I wouldn’t have opened a gallery if I’d stayed in New York, because I understood what my path would look like,” says Hoffman, who plans to “bounce” between historical and contemporary shows. She’s kicking off her program with an exhibition devoted to the late Brazilian artist Mira Schendel before moving on to a group show of young Los Angeles artists (among them, W up-and-comer Sam Falls). “Not only is L.A. new to me, but the role of galleries here is less codified—there’s so much space both physically and conceptually.”—D.S.